Was the son of Lorenzo & Anna Marie (Buchanan) Uncles,of East Baltimore.He became one of the first African-American to be ordained a Roman Catholic priest, in the United States (the first being Augustus Tolton).Charles was one of the founders of the St. Joseph's Society of the Sacred Heart,formed to minister to the African American community.
The Mill Hill Missionary Society recruited a number of candidates to become priests for their North American mission.Charles was the only of these candidates,who studied at studied at St.Peter's Apostolic School in Liverpool,England,to become a priest.On returning to the USA,he studied at St.Joseph Seminary in Baltimore.
He was ordained in December 1891 at the Cathedral of the Assumption by Cardinal James Gibbons.He celebrated his first Mass on Christmas day.
From 1891-1925 Father Uncles taught mainly Epiphany College in Baltimore and New Windsor,New York.He was of the founding members of the St.Joseph's Society of the sacred Heart in Baltimore in 1893,also known as the Josephite Fathers.
While residing at Epiphany College,Charles fell ill and died.He is buried in Calvary Cemtery.
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